#16 seed: Only one 16 seed has ever taken a #1 seed to OT (Purdue beat Western Carolina 73-71 in 1996)
What this means: Whatever you, don't pick a 16 seed to upset a #1 seed.
#15 seed: The last to win a game was Hampton in 2001
What this means: While a couple 15 seeds have won a game, don't start picking upsets until the 14 seeds
#14 seed:Only 2 have made the Sweet 16 since 1985 (1986 Cleveland State and 1997 Chattanooga)
What this means: Over the last decade, Cinderella runs have focused on 12 or 11 seeds. Perhaps this year will be different?
#13 seed: Morehead St won a game last year.
What this means: While everyone focuses on 12 over 5 upsets, there's a decent chance a 13 will win a game this year (they just might not go to Sweet 16.)
#12 seed: At least one 12 seed has made the Sweet 16 each year since 2008 (including Richmond in 2011)
What this means: 12 seeds have been hot in recent years, ride the wave and pick a 12 seed to reach the Sweet 16 again.
#11 seed: VCU made it to the Final 4 as an 11 seed in 2011
What this means: The last few years have shown how much parity there is in college basketball.
#10 seed: Florida St made the Sweet 16 in 2011 from this spot.
What this means: Teams that play great D, like FSU and Butler last year, can always be dangerous in the tourney.
#9 seed: Only four 9 seeds have made the Sweet 16 since 1985 (1992 UTEP, 1994 BC, 2004 UAB, 2010 UNI)
What this means: 9 seeds often beat 8 seeds, but 8 seeds rarely win another game.
#8 seed: Only 4 8 seeds have made it to the Final 4 since 1985 (1985 Villanova [won title], 2000 WI, 2000 NC, 2011 Butler)
What this means: If an 8 seed knocks off a #1 seed in the 2nd round, they can easily run to the Final Four.
#7 seed: The last to make the Sweet 16 was WVU in 2008
What this means: 6 and 7 seeds are often overrated power conference teams that fizzle out early.
#6 seed: The last 6 seeds to make the Sweet 16 were Xavier and Tennessee (both in 2010)
What this means: See 7 seed above.
#5 seed: The last 5 seeds to make the Final Four were Butler and Michigan St (both in 2010)
What this means: Although 5's struggle against 12's in the opening round, once they get through, look out.
#4 seed: Only two 4 seeds have reached the title game since 1985 (1996 Syracuse, 1997 national champ Arizona)
What this means: While 4 seeds are usually Top 20 pedigree teams, don't pick one to win it all.
#3 seed: Four 3 seeds have won the title (1989 MI, 2003 Syracuse, 2006 Florida, 2011 Connecticut)
What this means: There's often been a substantial jump in success between 3 and 4 seeds.
#2 seed: Great in the 2nd round if they made it to their conference tourney final, but below-average if they did not.
What this means: When 2 seeds fizzle out in their conference tourneys, its usually a sign of things to come.
#1 seed: Only twice since 1985 has there been a Final 4 without at least one #1 seed (2006 and 2011)
What this means: It's fun to have a risky bracket, but silly not to pick a Final Four without a 1 seed.